Radioimmunotherapy with Yettrium90 - Ibritumomab Tiuxetan(Zevalin): A novel therapeutic approach in patients with non Hodgkin’s lymphoma
Abstract
Non Hodgkin’s Lymphoma (NHL):
NHL represents group of closely related B-and T-cell malignancies of the lymphatic system .Most NHL are of B cell origin and express surface antigenCD20. The incidence of NHL has increased substantially in the past 20 years, now it ranks fifth in cancer incidence and mortality. The increasing incidence is poorly understood (1). NHL’s are divided clinically into aggressive or high grade lymphoma and indolent or low grade lymphoma. High grade lymphomas grow rapidly, have in
general rapidly developing symptoms, but are potentially curable, they represent 65% of NHL’s. Diffuse large B cell lymphoma (31% of all NHL subtypes) is the commonest aggressive type. While low grade lymphomas grow slower, have in general slower developing symptoms, most patients relapse after treatment , they represent 35% of NHL’s, follicular lymphoma (22% of all NHL subtypes)is the commonest indolent type 2,3.
NHL represents group of closely related B-and T-cell malignancies of the lymphatic system .Most NHL are of B cell origin and express surface antigenCD20. The incidence of NHL has increased substantially in the past 20 years, now it ranks fifth in cancer incidence and mortality. The increasing incidence is poorly understood (1). NHL’s are divided clinically into aggressive or high grade lymphoma and indolent or low grade lymphoma. High grade lymphomas grow rapidly, have in
general rapidly developing symptoms, but are potentially curable, they represent 65% of NHL’s. Diffuse large B cell lymphoma (31% of all NHL subtypes) is the commonest aggressive type. While low grade lymphomas grow slower, have in general slower developing symptoms, most patients relapse after treatment , they represent 35% of NHL’s, follicular lymphoma (22% of all NHL subtypes)is the commonest indolent type 2,3.