Antimullerian Hormone as a Marker for Severity of Endometriosis : A pilot study
Abstract
Objective: Evaluation of the value of the serum anti müllerian hormone (AMH) level for the prediction of severity of endometriosis among infertile women.
Study design: Cross sectional study.
Patients and methods: This study was conducted on twenty five infertile women visiting the gynaecology outpatient clinic at Kasr Al-Ainy University hospital ranging between 20-39 years of age who have undergone laparoscopy and were diagnosed to have endometriosis. Blood samples were withdrawn on cycle’s days 5-12 for assessment of serum AMH and the values obtained were correlated with the severity of the disease.
Results: Sixty percent of the patients classified as first stage endometriosis, had AMH serum level below the normal level, besides that, (55.5%) of the patients classified as second stage endometriosis had AMH serum level below the normal level. In the same way, (44.4%) of the patients classified as third stage endometriosis had AMH serum level below the normal level and finally, (100%) of the patients classified as fourth stage endometriosis had AMH serum level below the normal level (Normal level: 1.3-2.3 ng/ml).
Conclusion: The findings of this study suggested that serum AMH may be a sensitive marker for prediction of the severity of endometriosis among infertile women.
Keywords: Endometriosis, Anti Mullerian Hormone, Pelvic pain, Ovarian reserve, Infertility
References
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Barnhart, K., & Dunsmoor-Su, R. . Coutifaris C (2002): Effect of endometriosis on in vitro fertilization. Fertil Steril. , 77, 1148-55. [Google Scholar]
Lemos, N. A., Arbo, E., Scalco, R., Weiler, E., Rosa, V., & Cunha-Filho, J. S. (2008). Decreased anti-Müllerian hormone and altered ovarian follicular cohort in infertile patients with mild/minimal endometriosis. Fertil Steril. 2008 May;89(5): 1064-8. Epub 2007 Jul, 10(5), 1064-8. pmid:17624337 [Google Scholar]
Jorgensen, N., Rajpert-De_Meyts, E., Graem, N., Müller, J., Cate, R. L., & Skakkebaek, N. E. (1999). Expression of anti-Müllerian hormone during normal and pathological gonadal development: association with differentiation of Sertoli and granulosa cells. Journal of Clinical Endocrinology and Metabolism, 84(10), 3836-3844. Retrieved from http://jcem.endojournals.org/cgi/doi/10.1210/jc.84.10.3836 doi:10.1210/jc.84.10.3836 [Google Scholar]
De_Vet, A., & Laven, J. S. (2002). de Jong FH, Themmen APN & Fauser BC (2002): Antimullerian hormone serum levels: a putative marker for ovarian aging. Fertility and Sterility, 77(2), 357-362. Retrieved from http://linkinghub.elsevier.com/retrieve/pii/S0015028201029934 doi:10.1016/S0015-0282(01)02993-4 [Google Scholar]
Seifer, D. B., & Maclaughlin, D. T. (2007). Mullerian Inhibiting Substance is an ovarian growth factor of emerging clinical significance. Fertil Steril. 2007 Sep;88(3): 539-46. Epub 2007 Jun 7. Review. PubMed PMID, 88(3), 539-46. pmid:17559842 [Google Scholar]
Shebl, O., Ebner, T., Sommergruber, M., Sir, A., & Tews, G. (2009). Anti muellerian hormone serum levels in women with endometriosis: a case-control study. Gynecol Endocrinol, 25(11), 713-6. Retrieved from http://informahealthcare.com/doi/abs/10.3109/09513590903159615 pmid:19903049 doi:10.3109/09513590903159615 [Google Scholar]
Gagné, D., Rivard, M., Pagé, M., Lépine, M., Platon, C., Shazand, K., . . . Gosselin, D. (2003). Development of a nonsurgical diagnostic tool for endometriosis based on the detection of endometrial leukocyte subsets and serum CA-125 levels. Fertility and Sterility, 80(4), 876-885. Retrieved from http://linkinghub.elsevier.com/retrieve/pii/S0015028203011531 doi:10.1016/S0015-0282(03)01153-1 [Google Scholar]
--
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