Adding GnRH Antagonist In IUI Cycles Decreased The Complications And Didn't Affect The Outcome In Women With PCOS

Abstract

Objectives: To assess the effect of adding GnRH antagonist in IUI cycles for women with PCOS on cycle outcome.

Methods: Two hundred and sixteen women diagnosed to have PCOS were enrolled in the study; they were randomly divided into two groups. In the study group, IUI was performed in stimulated cycles conducted with Recombinant FSH and when the leading follicle reached at least 18 mm, Daily cetrorelix was administered until the day of hCG trigger, followed by inseminations at 36 hours after hCG. In the control group, Stimulation was conducted with Recombinant FSH until the day of hCG trigger, followed by inseminations at 36 hours after hCG. All patients received luteal support with Progesterone suppositories.

Results: Pregnancy rate was not significantly different in the study group (p= 0.16), Multiple pregnancy rate and OHSS were significantly lower in the study group (p= 0.036 and 0.026) respectively. While Spontaneous abortion rate was not statistically different between the study and the control group (p= 0.35).

Conclusion: Adding GnRH antagonist in IUI cycles decreased ovarian hyperstimulation syndrome and multiple pregnancies and didn't affect the pregnancy and miscarriage rates in women with PCOS.

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