Are There Detrimental Cut-offs For Progesterone And/or progesterone/estradiol ratio on the day of hCG administration among blastocyst transfers?
Abstract
Objective: To identify if there are certain cutoff levels for progesterone and/or (progesterone / estradiol ratio) on the day of human chorionic gonadotrophin that would be defined as detrimental for pregnancy.
Study Design: Cohort study.
Participants and Methods: On day of hCG, serum levels of progesterone (P) and estradiol were determined, as well as, the serum progesterone/estradiol ratio was calculated in a total of 183 women, who had shown cavitating blastocyst-stage embryos on day 5 and underwent day 5 blastocyst embryo transfer (BET).
Results: Using ROC, there were no detrimental cut offs, neither for P (AUC was 0.51, 95% CI=0.43-0.59) nor for P/E2 ratio (AUC was 0.52, 95%CI=0.44-0.61) for occurrence of clinical pregnancy among women undergoing day 5 (BET). Pregnant women and those who did not achieve pregnancy were balanced in respect of the patients and ICSI cycle characteristics. For ongoing pregnancy/live birth (LB), using ROC, there were no detrimental cut offs, neither for P (AUC was 0.49, 95% CI = 0.41 - 0.58), nor for P/E2 ratio (AUC was 0.51, CI = 0.43- 0.60) among these women.
Conclusions: No detrimental cutoff levels for progesterone and progesterone/estradiol ratio on the day of HCG among women undergoing BET, whether for clinical or ongoing pregnancy and live birth.
Study Design: Cohort study.
Participants and Methods: On day of hCG, serum levels of progesterone (P) and estradiol were determined, as well as, the serum progesterone/estradiol ratio was calculated in a total of 183 women, who had shown cavitating blastocyst-stage embryos on day 5 and underwent day 5 blastocyst embryo transfer (BET).
Results: Using ROC, there were no detrimental cut offs, neither for P (AUC was 0.51, 95% CI=0.43-0.59) nor for P/E2 ratio (AUC was 0.52, 95%CI=0.44-0.61) for occurrence of clinical pregnancy among women undergoing day 5 (BET). Pregnant women and those who did not achieve pregnancy were balanced in respect of the patients and ICSI cycle characteristics. For ongoing pregnancy/live birth (LB), using ROC, there were no detrimental cut offs, neither for P (AUC was 0.49, 95% CI = 0.41 - 0.58), nor for P/E2 ratio (AUC was 0.51, CI = 0.43- 0.60) among these women.
Conclusions: No detrimental cutoff levels for progesterone and progesterone/estradiol ratio on the day of HCG among women undergoing BET, whether for clinical or ongoing pregnancy and live birth.